|. . . . Information and Availability of Naturally Occuring Mind Altering Substances . . . .
Mescaline (C11H17NO3), also called 3,4,5-trimethoxy-phenethylamine,
is a naturally-occurring phenethylamine class psychedelic alkaloid. It has
been used as a recreational drug, an entheogen, and as a tool for
exploring altered states of consciousness.
It is found in nature in a number of cactus species including Peyote (Lophophora
williamsii), San Pedro (Echinopsis pachanoi) and Peruvian Torch (Echinopsis
peruviana), among others. It is also found in certain members of the
bean family, including Acacia berlandieri.
Peyote has been used ceremonially by Native Americans in Mexico for over
3000 years. Mescaline was first identified and isolated in 1897 by
Arthur Heffter, and first synthesized in 1919 by Ernst Späth. Aldour
Huxley famously experimented with mescaline and wrote of its "profound
alterations of consciousness" in The Doors of Perception. Other famous
users include Aleister Crowley, and Havelock Ellis.
The effective human dosage is 200–500 milligrams of pure mescaline.
Hallucinations occur at 300–600mg. Interestingly, dosages at the lower
end of these ranges have been described as having a subjective quality
of experience very similar to a low dose of MDMA or "Ecstasy".
Mescaline acts similarly to some other psychedelic agents in that it
binds to, and activates the (serotonin) 5-HT2A receptor with a high
nanomolar affinity. How such receptor activation leads to hallucinations
is still unknown, but it likely somehow involves exciting cortical
neurons. Between 20 and 50% of mescaline is excreted in the urine
unchanged, and the rest is excreted as the carboxylic acid form of
mescaline, a likely result of MAO degradation.
- Threshold 100 mg
- Light 100 - 200 mg
- Common 200 - 300 mg
- Strong 300 - 500 mg
- Heavy 500 - 700 mg
PiHKAL Entry - Mescaline
Mescaline is an illegal drug in most/all countries, however, some mescaline
containing plant material is sometimes legal to possess in certain
countries. See the Erowid Law page on mescaline for more info.
"DMT is a neurotransmitter that, when ingested and allowed to come to rest in unusually large amounts in the synapses of the brain, allows one to see sound [synaesthesia], so that one can use the voice to produce not musical compositions, but pictorial and visual compositions. This, to my mind, indicates that we're on the cusp of some kind of evolutionary transition in the language-forming area, so that we are going to go from a language that is heard to a language that is seen, through a shift in interior processing." - Terence McKenna - The Archaic Revival
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